Anastrozole is in the category of drugs called Aromatase Inhibitors (AIs) and AIs alongside Selective Estrogen Receptor Modulators (SERMs) are forming up the wider class of drugs known as anti estrogens.
Therefore, both AIs and SERMs are anti estrogens, but they are still in 2 different sub categories because although they both deal with estrogen related issues, the mechanism of action is completely different.
SERMs block the action of estrogen in specific tissues, AIs are preventing aromatization into estrogen and therefore lowering total estrogen levels in the body.
Anastrozole is the active substance in the brand Arimidex. Anastrozole was developed by AstraZeneca and sold as Arimidex – that’s why, despite there being a lot of other trade names except for Arimidex, this one remains the most popular one.
It was developed and then approved by FDA for treatment of female breast cancer because it was discovered that most breast cancers require estrogen to grow.
Since Anastrozole (Arimidex) lowers levels of estrogen, it is helpful for such purposes.
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Anastrozole (Arimidex) is considered to be one of the newer aromatase inhibitors (AIs) known as the third generation of AI.
Anastrozole (Arimidex) Bodybuilding
Arimidex – Anastrozole was one of the very first aromatase inhibitors that many bodybuilders have taken notice of, part of the reason is because is one of the most effective AI out there, therefore is considered that Anastrozole is the most popular AI among bodybuilders and athletes using steroids to control the estrogen levels.
This compound is very effective in dealing and lowering total levels of estrogen, and is considered a very powerful one.
- Therefore, is very effective in dealing with all estrogen related side effects such as gynecomastia, hypertension, water retention and bloating, loss of energy and libido and many others.
In contrast, SERMs can’t be as helpful because although they block the action of estrogen, they mostly do it in breast tissues, meaning that they might be helpful with gyno, but they won’t be helpful for other estrogen related issues.
- Arimidex (Anastrozole) is sometimes used by bodybuilders as a part of Post Cycle Therapy (PCT) plan to boost testosterone levels.
However, the compound is not as effective at boosting them and may suppress estrogen too much. That’s why SERMs are more popular for PCT – they are doing a better job for increasing testosterone levels after a cycle with steroids.
Anastrozole (Arimidex) Properties
Is important to remember that Arimidex – Anastrozole is a powerful AI that is capable of drastically reducing the levels of estrogen from 1 mg dosage per day. That’s why many bodybuilders start at way lower doses of 0.5mg every other day (because it has a long half life, you might use it every other day).
Studies done prove that estrogen levels are reduced by over 80% in patients with such doses. That’s why it is recommended to steroid users to start slower and reach such doses with time as they get a feeling of the compound.
Rarely someone using anabolic steroids would ever need more than 1 mg per day of Anastrozole (Arimidex) because even this dosage is way too much for most people.
Anastrozole (Arimidex) Side Effects
The compound is binding to the aromatase enzymes and is blocking the conversion into estrogen, with this being said, the side effects that appear from Anastrozole is due to low levels of estrogen as a result of using too much of this compound.
When Anastrozole – Arimidex is used in proper doses, the compound is virtually not offering any side effects, especially in men who generally need way lower doses, run it for shorter periods than women and do not need as much estrogen as women do.
The primary side effects of Anastrozole is the result of too much estrogen shrinkage and long term estrogen suppression. That’s why the compound affects females way more significantly than males.
Conclusion
Anastrozole (Arimidex) is a very powerful AI and hence should be used properly. But since most anabolic steroids are converted into estrogen, is very important to deal with this issue and this compound is one of the best out there, no wonder it is most popular.
With this being said, everyone running anabolic steroid cycles are very recommended to add Arimidex into their aromatizable steroid cycle or at least to have it handy in case estrogen levels spike.
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